2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide FF Receptor

Neuropeptide FF Receptor

Neuropeptide FF Receptor

Neuropeptide FF Receptor (NPFFR) is a type of G Protein-Coupled Receptor (GPCR) belonging to the RFamide receptor subfamily, specifically binding to neuropeptide FF (NPFF) and its analogous peptides (such as NPAF, NPSF).
NPFFR has two subtypes: NPFFR1 (GPR147) and NPFFR2 (GPR74), and these receptors regulate a variety of physiological functions, including modulation of pain, opioid side effects, feeding, drug reward, anxiety, cardiac function, and control of insulin release, among others.
Based on its pleiotropic functions, NPFFR is considered a potential target for the treatment of chronic pain, opioid dependence, metabolic diseases (such as obesity), and anxiety disorders[1][2].

Neuropeptide FF Receptor Isoform Specific Products:

Neuropeptide FF Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1248
    Neuropeptide FF
    		99.35%
    Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain.
    Neuropeptide FF
  • HY-124680
    AC-263093 free base
    		Inhibitor 99.66%
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
    .
    AC-263093 free base
  • HY-P10377
    GUB03385
    		Agonist
    GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM). GUB03385 has anti-obesity effect.
    GUB03385
  • HY-P10380A
    palm11-PrRP31 TFA
    		Agonist 99.44%
    palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
    palm11-PrRP31 TFA
  • HY-161405
    NPFF1-R antagonist 1
    		Inhibitor 99.38%
    NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
    NPFF1-R antagonist 1
  • HY-P11811
    GUB10194
    GUB10194 is a fully potent and selective GPR10 agonist with an EC50 of 15 nM. GUB10194 does not significantly affect body weight or food intake.
    GUB10194
  • HY-P11810
    GUB08248
    		Agonist
    GUB08248 is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research.
    GUB08248
  • HY-154829A
    AC-099 hydrochloride
    		Agonist 99.92%
    AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats.
    AC-099 hydrochloride
  • HY-P10395
    DP50
    		Antagonist
    DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research.
    DP50
  • HY-P10379
    palm-PrRP31
    		Agonist
    palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure.
    palm-PrRP31
  • HY-P3873
    Neuropeptide FF (5-8)
    Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a Ki value of 20.9 nM.
    Neuropeptide FF (5-8)
  • HY-P3945
    Prolactin-Releasing Peptide (12-31), bovine
    Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP). PrRP is RF-amide peptides expressed in brain areas involved in pain modulation. Prolactin-Releasing Peptide (12-31), bovine can be used for the research of nervous system disease.
    Prolactin-Releasing Peptide (12-31), bovine
  • HY-P10380
    palm11-PrRP31
    		Agonist
    palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
    palm11-PrRP31
  • HY-P10780
    RFRP-3 (mouse)
    		Modulator 98.82%
    RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.
    RFRP-3 (mouse)
  • HY-P10394
    DP32
    		Antagonist
    DP32 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP32 can be used in analgesia-related research.
    DP32
  • HY-186010
    NPFFR2 modulator-1
    NPFFR2 modulator-1 (compound 11) is a NPFFR2 modulator.
    NPFFR2 modulator-1
  • HY-154829
    AC-099
    		Agonist
    AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats.
    AC-099
  • HY-161382
    NPFF2-R ligand 1
    		Ligand
    NPFF2-R ligand 1 (Compound 16a) is a NPFF2-R ligand, with Kis of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system.
    NPFF2-R ligand 1
Neuropeptide FF Receptor Isoform Comparison

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